We fully agree with their assumption and try to give some detailed insights into this issue by replicating the respiratory circuits and calculating the actual dead space effect. already mentioned differences in dead space which may provide an explanation for the somewhat contradictory results.

Notwithstanding this, the authors draw overall positive conclusions regarding the clinical applicability and efficacy of FCV.

At first sight, this may appear to be strange as better aeration is normally associated with better gas exchange. The results show a slightly better and more homogeneous lung aeration in FCV, but inferior gas exchange compared to PRVC. This paper provides valuable insights into FCV and associated phenomena at very low tidal volumes. Recently, Álmos Schranc and colleagues published a most interesting experimental study comparing flow-controlled ventilation (FCV) to pressure-regulated volume-controlled ventilation (PRVC) in a pediatric pig-model of healthy and surfactant depleted, injured lungs ( 1). Flow-controlled ventilation maintains gas exchange and lung aeration in a pediatric model of healthy and injured lungs: a randomized cross-over experimental studyīy Enk D, Spraider P, Abram J, Barnes T.

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